Blastocystis Subtype 4 increases intestinal permeability and provokes programmed dell death in intestinal enterocytes

Researchers working with human enterocytes, columnal cells found in the intestine, report that exposure to Blastocystis sp. subtype 7 significantly reduces intestinal permeability, a property common to many intestinal pathogens, and one cause of the symptom of diarrhea.  Exposure to Blastocystis sp. subtype 7 also produced a statistically significant increase in programmed cell death in enterocytes.  Similar exposure to Blastocystis sp. subype 4 did not produce these effects, suggesting the existence of a strain-dependent effect.  For additional information, please refer to the paper from Biomed Research International.

 

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